There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Results of In Vitro Testing with SILVADENE ® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Results from in vitro testing are listed below. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. WADA Class View World Anti-Doping Agency classifications.Silver sulfadiazine has broad antimicrobial activity. This does not necessarily mean no interactions exist. 45 moderate drug interactions (205 brand and generic names).2 major drug interactions (3 brand and generic names).49 moderate drug interactions (360 brand and generic names)Ī total of 49 drugs are known to interact with Silvadene:Ī total of 47 drugs are known to interact with lidocaine topical:.See the full pregnancy warnings document.Ī total of 49 drugs are known to interact with silver sulfadiazine topical: Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. Other silver sulfadiazine brands include: Silvadene Cream 1%, SSD, ThermazeneĪloe Vera Burn Relief Spray with Lidocaine, AneCream, AneCream with Tegaderm, Anestacon, Anestafoam, Apicaine-X, Aspercreme Maximum Strength Lidocaine Creme, Aspercreme Maximum Strength Lidocaine Patch, Astero, Bactine, Bruselix Gel, CidalEaze, Derma Numb, DermacinRx Lido V Pak, DermacinRx Lidotral, Dermaflex, Eha Lotion, Ela-Max, Ela-Max 5, Gen7T Lotion, Gen7T Patch, Glydo, LidaMantle, Lido-K, Lido-Sorb, Lidocaine Viscous, Lidocan II, Lidocan III, Lidocan IV, Lidocan Patch, Lidocan V, Lidocanna, Lidocream, Lidoderm, Lidogel, LidoLite, Lidopac, Lidopin, Lidorex, LidoRx, Lidosol, Lidotran, Lidotrans 5 Pak, Lidovex, Lidozion, Lidozol, LMX 4, LMX 4 with Tegaderm, LMX 5, LTA II Kit, Lydexa, Medi-Quik Spray, Moxicaine, RadiaGuard, RectiCare, Regenecare HA Spray, Topicaine, Tranzarel, Uro-Jet, Uro-Jet AC, Xylocaine Jelly, Xylocaine Topical, Zensa, Zionodil, ZTlido View more Silvadene, Silvadene Cream 1%, SSD, Thermazene Pricing and Coupons * Prices are without insurance See also: lidocaine topical side effects in more detail. See also: Silvadene side effects in more detail. See also: silver sulfadiazine topical side effects in more detail. ![]() Lidocaine topical has an average rating ofģ1% of reviewers reported a positive effect, while 56% reported a negative effect. ![]() Silver sulfadiazine topical has an average rating ofĩ9% of reviewers reported a positive effect, while 1% reported a negative effect.ġ00% of reviewers reported a positive effect, while 0% reported a negative effect. Aloe Vera Burn Relief Spray with Lidocaine.
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